026 Serum CIRPcold-inducible RNA-binding protein levels as a potentialnovel biomarker for systemic sclerosis-associated interstitial lung disease in systemic sclerosis

Systemic sclerosis (SSc) is a chronic autoimmune disorder resulting in excessive fibrosis of the skin, lungs, and other internal organs. In particular, interstitial lung disease (ILD) common manifestation SSc leading cause death. SSc-associated ILD (SSc-ILD) runs highly variable course, novel markers are required to predict or evaluate prognosis activity SSc-ILD. Recently, danger-associated molecular patterns (DAMPs)-mediated inflammasome has been attracting attention as part disease-associated molecules idiopathic pulmonary (IPF). Cold-inducible RNA-binding protein (CIRP) nuclear that known act DAMPs. CIRP general stress-response ubiquitously expressed various tissues, such heart. Recent studies have discovered endowed with extracellular signaling functions on cell types stimulates cytokine release. reported be involved pathogenesis IPF. However, involvement not well known. This study measured serum levels patients investigate associations clinical symptoms complications. Here we found were elevated especially diffuse cutaneous patients. Further analysis revealed higher than those without ILD, suggesting can potential marker identify high-risk Although further clarify specific role development SSc-ILD, our results indicate may serve useful SSc-ILD therapeutic effects. We believe this work potentially lead considering treatment strategy for